Grid 2.5 doesn't have serious changes in API, so most functionality will work without any changes.
Grid 2.5 will work only with the latest dhtmlxcommon.js (if you have an error “dhtmlx” is undefined - you are using incorrect dhtmlxcommon.js).
If you are using custom paging template, beware that while in older version “prevpages” and “prev” were related to the same control, in new version these are two different elements (the first scroll group of pages, the second the active page only).
If you are using compiled file (dhtmlx.js), beware that version included in package is compiled with dhx_skyblue skin, so if you have used dhx_blue or dhx_black skin, you need to recompile it with necessary skin, or migrate to dhx_skyblue (it doesn't affect all grid-specific skins such as xp, modern, light).